One thing that in-vitro diagnostics people know is that new markers never seem to turn out as good as the initial publications. This has now been studied and is available, here. Included in this analysis are CRP, prostate markers, and others. Ioannidis and Panagiotou compared the initial publication results with meta-analysis and larger study results and confirmed that the effects claimed in the initial publications were often found not to be as large in the larger study or meta-analysis.
If the initial study were unbiased, one would expect the larger studies would show greater effects half of the time and less effects the other half.