EPCA-2 update number 4

February 20, 2010

Dr. Diamandis has published an opinion about EPCA2 at: http://www.clinchem.org/cgi/reprint/clinchem.2009.140061v1 Since a subscription is required, here is the gist of Dr. Diamandis’s contribution. First, he mentions that Dr. Getzenberg has published a new article about EPCA-2 (1) (subscription also required). In the Getzenberg article, Dr. Diamandis says that the claim has been dropped by Dr. Getzenberg that EPCA-2 distinguishes between organ confined and non organ confined prostate cancer. Otherwise, the Prostate article validates Getzenberg’s other previous claims about the EPCA-2 marker. The abstract is at: http://www3.interscience.wiley.com/journal/122373646/abstract?CRETRY=1&SRETRY=0

Dr. Diamandis’s Clinical Chemistry article says that according to ELISA assay principles and now demonstrated experimentally, the Getzenberg assay was incapable of measuring EPCA-2 at the levels claimed and thus, the results had could only be explained by some sort of bias.

So the story continues.


  1. Leman ES, Magheli A, Canon GW, Mangold L, Partin AW, Getzenberg RH. Analysis of a serum test for prostate cancer that detects a second epitope of EPCA-2. Prostate 2009;69:1188 –94.